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Download PDF by Jesse P. Greenstein and Alexander Haddow: Advances in Cancer Research, Vol. 2

By Jesse P. Greenstein and Alexander Haddow

ISBN-10: 0120066025

ISBN-13: 9780120066025

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Extra resources for Advances in Cancer Research, Vol. 2

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One suggestion is that they polymerize and that the side chains then bring about crosslinking with multipoint attachment of two protein or nucleoprotein chains of chromosomal origin. Another suggestion is that one arm of the monomeric form reacts with a cell compound followed by self condensation via the second reactive group. The polymerization hypothesis finds a measure of support from the fact that ethylene imines can polymerize under mild conditions according to this reaction: R I R I R The corresponding reaction with epoxides has also been recorded though only in alkaline media.

These alkylating agents do not appear to esterify carboxyl groups, but in every case react with amino groups. These groups are also involved in the crosslinks formed in wool since fibers in which the amino groups have been blocked by acetylation cannot be crosslinked with epoxides or mesyloxy compounds. C. Main Chain Degradation. Reaction of alkylating agents with the peptide bond is not impossible and Blackburn et al. (1941) showed that the number of methyl groups introduced into wool and silk by methyliodide and dimethylsulfate is greater than the number of carboxyl groups present.

That all mustard ester groups had been saponified). Carpenter et al. , 1949) approximately 50% and with collagen (Pirie, 1946) approximately 70% of the mustard gas combined could be removed with alkali, Pirie (1947) found that the physical properties of collagen were greatly modified by reaction with mustard gas, and in the reviewer’s opinion these changes indicate extensive crosslinking. This is supported by the fact that the treated collagen is no longer digested by pepsin. , 1952). All these investigations indicate that mustard gas combines with carboxyl groups in proteins under physiological conditions, but that only a small proportion are available for reaction ; this reaction, however, accounts in general only for about half of the mustard gas combined.

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Advances in Cancer Research, Vol. 2 by Jesse P. Greenstein and Alexander Haddow


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