By Andrei G. Pakhomov, Damijan Miklavcic, Marko S. Markov
"A mirrored image of the serious examine of the consequences of electromagnetic fields on dwelling tissues that has taken position over the past a number of many years, this ebook discusses the theoretical and experimental proof and concerns the results of sturdy electromagnetic fields and/or electrical pulses and their significance in medication and biology. The authors current the fundamental concepts utilized in electroporation and the complex tools for production of nanopores, highlighting their simple technological know-how and scientific functions. themes comprise nano electroporation, vintage electroporaiton, experimental facts for electroporation of dwelling cells, and electroporation for melanoma and wound healing"--Provided by way of writer. learn more... content material: fundamentals of Electroporation actual Chemical thought of Membrane Electroporation and Electrotransfer of Biogenic brokers, E. Neumann and S. Kakorin Bioelectric influence of severe Nanosecond Pulses, K.H. Schoenbach prompted Transmembrane Voltage-Theory, Modeling, and Experiments, T. Kotnik and G. Pucihar Electroporation: A overview of uncomplicated difficulties in concept and test, M.S. Markov Mechanisms of Electroporation in Lipid platforms Electrodeformation, Electroporation, and Electrofusion of Cell-Sized Lipid Vesicles, R. Dimova Fluorescent tools in review of Nanopore Conductivity and Their Computational Validation, M. Kotulska, W. Dyrka, and P. Sadowski Electroporation of Lipid Membranes: Insights from Molecular Dynamics Simulations, M. Tarek and L. Delemotte Nanoscale Restructuring of Lipid Bilayers in Nanosecond electrical Fields, P.T. Vernier Mechanisms of Electroporation of Cells Nanopores: a unique Transmembrane Passageway in Electroporated Cells, A.G. Pakhomov and O.N. Pakhomova version of mobilephone Membrane Electroporation and Transmembrane Molecular shipping, D. Miklavcic and L. Towhidi Kinetics of Pore Formation and Disappearance within the mobile in the course of Electroporation, G. Saulis the heartbeat Intensity-Duration Dependency for phone Membrane Electroporation, D. Miklavcic, G. Pucihar, A.M. Lebar, J. Krmelj, and L. Towhidi Mechanisms of Electroporation in Tissues Drug-Free, reliable Tumor Ablation by way of Electroporating Pulses: Mechanisms That Couple to Necrotic and Apoptotic mobilephone demise Pathways, A.T. Esser, K.C. Smith, T.R. Gowrishankar, and J.C. Weaver Gene Electrotransfer: From uncomplicated methods to Preclinical functions, J.-M. Escoffre, A. Paganin-Gioanni, E. Bellard, M. Golzio, M.-P. Rols, and J. Teissie Technical concerns Modeling electrical box Distribution In Vivo, N. Pavselj, A. Zupanic, and D. Miklavcic strategies of Electroporation Pulse new release and assessment of electrical Pulse turbines for phone and Tissue Electroporation, M. Rebersek and D. Miklavcic iteration of Ultrashort Pulses, J.F. Kolb Nanosecond Pulsed electrical box supply to organic Samples: problems and strength strategies, A. Silve, J. Villemejane, V. Joubert, A. Ivorra, and L.M. Mir purposes of Electroporation Translation of Electroporation-Mediated DNA supply to the medical institution, L.C. Heller and R. Heller scientific Electrochemotherapy: The Italian event, C.R. Rossi and L.G. Campana Tumor Blood Flow-Modifying results of Electroporation and Electrochemotherapy-Experimental proof and Implications for the treatment, T. Jarm, M. Cemazar, and G. Sersa lectrochemotherapy as a part of an Immunotherapy procedure within the therapy of melanoma, J. Gehl ombined electric box and Ultrasound: A Nondrug-Based strategy for Tumor Ablation, P.F. Forde, C. Twomey, G.C. O' Sullivan, and D. M. Soden mixed Modality remedy: Electrochemotherapy with Tumor Irradiation, G. Sersa, S. Kranjc, and M. Cemazar Irreversible Electroporation in drugs, B. Rubinsky foodstuff and Biomaterials Processing Assisted through Electroporation, N. Lebovka and E. Vorobiev In Vivo Electroporation: an enormous damage Mechanism in electric surprise Trauma, I. Barakat, J. Gallaher, H. Chen, and R.C. Lee Index summary: Reflecting the serious learn of the results of electromagnetic fields on dwelling tissues that has taken position through the years, this name summarizes the experimental findings and theories concerning permeabilization of biomembranes through pulsed electrical fields. it really is meant extensively for biomedical and actual scientists, engineers, and clinicians. learn more...
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Additional info for Advanced electroporation techniques in biology and medicine
The mitochondrial membranes. , 2002) and/or mitochondrial membrane voltage-dependent anion channels (Savill and Haslett, 1995; Tsujimot and Shimizu, 2002). Weaver’s hypothesis is that ultrashort pulses change the transmembrane voltage at mitochondrial membrane sites, which leads to an opening of the MPTP, inducing apoptosis (Weaver, 2003). , 2006). There is evidence that nsPEF stimulation with multiple, intense pulses causes damage to DNA or other critical proteins. 14). Some DNA repair was observed when the permeabilization of the cells for the comet assay was delayed for an hour.
2009, Intracellular DNA damage induced by non-thermal, intense narrowband electric fields, IEEE Trans. Dielect. Electr. , 16, 1288–1293. , 2006, Nanosecond pulsed electric fields cause melanomas to self-destruct, Biochem. Biophys. Res. , 343, 351–360. , Ren, W. , 2009, A new pulsed electric field therapy for melanoma disrupts the tumor’s blood supply and causes complete remission without recurrence, Int. J. Cancer, 125, 438–445. , 2007, Membrane permeabilization and cell damage by ultrashort electric field shocks, Arch.
Thus, ultrashort pulses and UTP cause intracellular calcium release followed by influx through calcium channels in the plasma membrane with similar kinetics. Fluorescence microscopy with a temporal resolution of milliseconds confirmed the ER as the likely source of calcium following pulse application (Scarlett et al. 2009). Other internal calcium stores, in particular mitochondria, might be affected in a similar way by these nanosecond pulses. However, the much smaller size of mitochondria, when compared with the volume filled by the ER, has prevented the temporal and spatial resolution of calcium release from these sources so far.
Advanced electroporation techniques in biology and medicine by Andrei G. Pakhomov, Damijan Miklavcic, Marko S. Markov