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By Susanne Klaus

ISBN-10: 1587060833

ISBN-13: 9781587060830

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2. Himms-Hagen J, Ricquier D. Brown Adipose Tissue. In: Bray GA, Bouchard C, James WPT, eds. Handbook of Obesity. New York: Marcel Dekker, 1998:415-441. 3. Cinti S. The Adipose Organ. Milano: Editrice Kurtis, 1999. 4. Carpentier JL, Perrelet A and Orci L. Morphological changes of the adipose cell plasma membrane during lipolysis. J Cell Biol 1997; 72(2):104-117. 5. Blanchette-Mackie EJ and Scow RO. Membrane continuities within cells and intercellular contacts in white adipose tissue of young rats.

The fine regulation of p18, p21 and p27 CKIs has allowed to define distinct states of growth arrest during clonal expansion and terminal differentiation. 84 Collectively, these observations indicate that PPAR# induces cell cycle withdrawal and terminal differentiation accompanied by irreversible growth arrest. 89 It is also of interest to note that C/EBP∀ and ∃ exhibit a delayed acquisition of DNA binding activity, between 12 and 16 h after induction of differentiation. This acquisition depends probably upon their phosphorylation, as it occurs immediately before phosphorylation of pRB and entry into the S phase of the cell cycle.

29 In aggregate, apoptosis does occur to some extent in WAT under drastic conditions including pharmacological treatment but its quantitative importance under physiological conditions remains questionable. White Adipose Tissue Requires a Few Hormones to Develop A limited number of hormones can affect both the adipose tissue mass and possibly its distribution pattern. This observation is consistent with the hormonal requirements observed in vitro for the differentiation of adipose precursor cells (vide infra).

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Adipose Tissues by Susanne Klaus

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