You are here

Download e-book for iPad: Activity-based protein profiling by Matthew B. Nodwell, Stephan A. Sieber (auth.), Stephan A.

By Matthew B. Nodwell, Stephan A. Sieber (auth.), Stephan A. Sieber (eds.)

ISBN-10: 3642283772

ISBN-13: 9783642283772

ISBN-10: 3642283780

ISBN-13: 9783642283789

ABPP technique: advent and review, by means of Matthew B. Nodwell und Stephan A. Sieber Activity-Based Protein Profiling for ordinary Product aim Discovery, via Joanna Krysiak und Rolf Breinbauer Photoaffinity Labeling in Activity-Based Protein Profiling, through Paul P. Geurink, Laurette M. Prely, Gijs A. van der Marel, Rainer Bischoff und Herman S. Overkleeft software of Activity-Based Protein Profiling to the learn of Microbial Pathogenesis, by means of William P. Heal und Edward W. Tate sensible research of Protein objectives by means of Metabolomic methods, by way of Yun-Gon Kim und Alan Saghatelian

Show description

Read or Download Activity-based protein profiling PDF

Similar nonfiction_6 books

Extra info for Activity-based protein profiling

Example text

One of the first glycosidase ABPP probe designs was adapted from a previously introduced latent quinone methide reactive group used for tyrosine phosphatases (Sect. 5). B. A. Sieber HO OH OH CO2Na O AcHN H CHF2 Sialidase O F H F F O – O HO N Tag H N Tag H N Tag H o-quinone methide HO OH OH CO2Na O AcHN OH HO Scheme 9 Activation of glycosidase ABPP probe by cleavage of sialic acid cleavage HO O H N3 O HO O LG HO O HO O O O HO F O O HO F O HO N3 OH H F – H O LG O– O N3 – O O Scheme 10 Trapping of fluoroglycosyl-enzyme intermediate for ABPP cleavage, the probe undergoes 1,6-elimination to form an electrophilic o-quinone methide (Scheme 9).

Nat Rev Mol Cell Biol 8:813–824 168. Poole LB, Nelson KJ (2008) Discovering mechanisms of signaling-mediated cysteine oxidation. Curr Opin Chem Biol 12:18–24 169. Reddie KG, Carroll KS (2008) Expanding the functional diversity of proteins through cysteine oxidation. Curr Opin Chem Biol 12:746–754 170. Benitez LV, Allison WS (1974) The inactivation of the acyl phosphatase activity catalyzed by the sulfenic acid form of glyceraldehyde 3-phosphate dehydrogenase by dimedone and olefins. J Biol Chem 249:6234–6243 171.

Amara N, Mashiach R, Amar D et al (2009) Covalent inhibition of bacterial quorum sensing. J Am Chem Soc 131:10610–10619 35. Liu S, Zhou B, Yang H et al (2008) Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases. J Am Chem Soc 130:8251–8260 36. Adam GC, Sorensen EJ, Cravatt BF (2002) Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype. Nat Biotechnol 20:805–809 37. Patricelli MP, Giang DK, Stamp LM et al (2001) Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes.

Download PDF sample

Activity-based protein profiling by Matthew B. Nodwell, Stephan A. Sieber (auth.), Stephan A. Sieber (eds.)

by Michael

Rated 4.04 of 5 – based on 13 votes