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Download e-book for iPad: ABC Transporters - 40 Years on by Anthony M. George

By Anthony M. George

ISBN-10: 3319234757

ISBN-13: 9783319234755

ISBN-10: 3319234765

ISBN-13: 9783319234762

This ebook presents new structural, biochemical, and scientific details on ABC transporters. The authors discover and describe the state-of-the-art of study, wisdom, and customers for the longer term for this crucial kin of proteins. the 1st ABC transporter was once came upon in 1973 and used to be named P-glycoprotein. It elicits resistance to cytotoxic medicines, mainly in human tumours, during which chemotherapy failure is saw in approximately 50% of instances. including its complicated pharmacology, or even a suspected function in Alzheimer’s sickness, this ABC transporter nonetheless eludes a scientific option to its multidrug resistance estate. ABC transporters are vital membrane energetic proteins and so they belong to at least one of the most important protein households throughout all species. Their myriad roles surround the import or export of a various diversity of allocrites, together with ion, food, peptides, polysaccharides, lipids, and xenobiotics. they're of significant clinical value with many participants elaborating multidrug resistance in micro organism, fungi, yeast, parasites, and people. different ABC transporters are enthusiastic about a couple of inherited illnesses, together with cystic fibrosis, macular degeneration, gout, and a number of other metabolic disorders

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Extra info for ABC Transporters - 40 Years on

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Structure 21:861–867 Manson M, Boos W, Bassford P, Rasmussen B (1985) Dependence of maltose transport and chemotaxis on the amount of maltose-binding protein. J Biol Chem 260:9727–9733 Nelson SO, Postma PW (1984) Interactions in vivo between IIIGlc of the phosphoenolpyruvate:sugar phosphotransferase system and the glycerol and maltose uptake systems of Salmonella typhimurium. Eur J Biochem 139:29–34 Neubauer O, Alfandega A, Schoknecht J, Sternberg U, Pohlmann A, Eitinger T (2009) Two essential arginine residues in the T components of energy-coupling factor transporters.

Nature 499:364–368 Clore GM (2014) Interplay between conformational selection and induced fit in multidomain protein-ligand binding probed by paramagnetic relaxation enhancement. Biophys Chem 186:3–12 Davidson AL, Dassa E, Orelle C, Chen J (2008) Structure, function, and evolution of bacterial ATP-binding cassette systems. Microbiol Mol Biol Rev 72:317–364 Dean DA, Reizer J, Nikaido H, Saier MH Jr (1991) Regulation of the maltose transport system of Escherichia coli by the glucose-specific enzyme III of the phosphoenolpyruvate-sugar phosphotransferase system.

2008), and underscored the importance of some of these new bacterial members in conferring antibiotic resistance on cells. In 2006, Piddock and coworkers described the overexpression of two genes encoding putative ABC half-transporters, patA (SP2075) and patB (SP2073), in multidrug resistant Streptococcus pneumoniae (Marrer et al. 2006a, b), which exhibited enhanced efflux of various drugs. In parallel, Robertson et al. (2005) inactivated 13 genes encoding putative efflux pumps in S. pneumoniae.

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ABC Transporters - 40 Years on by Anthony M. George

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